Cinnamic acids and derivatives
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 5 MG
Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 5 MG
Medchemexpress LLC Tyrphostin AG 112 | 144978-82-5 | 98.3% | 236.23 | 10 MG
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor, intended for research use only.
- Inhibits EGFR phosphorylation.
- Detailed solubility information for in vitro and in vivo applications is available.
- Comprehensive documentation including Data Sheet, COA, SDS, HNMR, LCMS, and Handling Instructions.
- Target: EGFR.
- Pathway: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK.
![Medchemexpress LLC 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- | 148741-30-4 | 99.3% | 316.46 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000402443-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- | 148741-30-4 | 99.3% | 316.46 | 25 MG
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation with an IC50 of 10 μM, but not TrKB and TrKC. It is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, showing at least 500-fold higher selectivity for ErbB2 over EGFR. This compound exhibits anticancer activity.
- Significantly decreases cell proliferation in various cell lines
- Induces a dose-dependent increase in apoptosis
- Reduces tumor sizes in animal models
Medchemexpress LLC SAR405 R enantiomer | 1946010-79-2 | 99.9% | 443.85 | C19H21ClF3N5O2 | 10MM 1ML
SAR405 R enantiomer is the less active enantiomer of SAR405, a selective inhibitor of PIK3C3/Vps34, supplied for research use. It is offered as a ready-to-use 10 mM solution in DMSO or as a solid, and is used as a reference or control in studies of autophagy, vesicle trafficking, and related signaling pathways.
- Less active enantiomer of a PIK3C3/Vps34 inhibitor.
- High purity (~99.9%) for reliable experimental controls.
- Available as 10 mM solution in DMSO and multiple solid package sizes.
- Soluble in DMSO at 100 mg/mL; ultrasonication may be required.
- Storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
- Intended for research use only, not for clinical applications.
Medchemexpress LLC Entacapone | 130929-57-6 | MFCD00866580 | >98.0% | 305.29 g/mol | C14H15N3O5 | 5 MG
Entacapone is a research-grade catechol-O-methyltransferase (COMT) inhibitor supplied as a small-scale reagent. It is potent, reversible, peripherally acting, and orally active, and is used in Parkinson's disease research and studies of FTO demethylation.
- Potent, reversible COMT inhibitor.
- Peripherally acting and orally active.
- Suitable for Parkinson's disease research.
- Inhibits FTO demethylation for metabolic research.
- Purity >98.0% (HPLC) reported by suppliers.
- Molecular formula C14H15N3O5; molecular weight 305.29 g/mol.
- Supplied as a small-scale research pack (5 mg).
Selleck Chemical LLC Tyrphostin AG 879 S2816-25mg
Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 M 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR
Medchemexpress LLC Trans,trans-2,4-hexadien-1-ol | 17102-64-6 | MFCD00002925 | >=97.0% | 98.14 g/mol | C6H10O | 5 G
(2E,4E)-Hexa-2,4-dien-1-ol (trans,trans-2,4-hexadien-1-ol) is a small unsaturated aliphatic alcohol used as a research reagent and synthetic intermediate. It is commonly supplied stabilized to reduce oxidation and is employed in organic synthesis and analytical applications. Key identifiers include CAS 17102-64-6 and formula C6H10O.
- Unsaturated aliphatic alcohol for organic synthesis and research
- Typically supplied stabilized to limit oxidation
- Typical purity ≥97.0%
- Chemical formula C6H10O; molecular weight 98.14 g/mol
- Suitable for small-scale laboratory and analytical use
![Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211898.png-250.jpg)
Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML
(+)-Tyrphostin B44 is the (+) enantiomer of Tyrphostin AG-835, a small-molecule inhibitor of the epidermal growth factor receptor (EGFR) used in biochemical and cellular research. It is provided as a concentrated solution in DMSO for in vitro assays and is documented with supporting datasheet, certificate of analysis, and safety data information.
- Provides EGFR inhibitory activity useful for signaling and cancer research.
- Supplied as a 10 mM solution in DMSO for ready-to-use preparations.
- High purity suitable for research applications (≈97%).
- Characterized molecular properties for accurate dosing in assays.
- Documentation available to support safe handling and experimental reproducibility.
Cayman Chemical CurcumIn-d6 500ug
An internal standard for the quantification of curcumin by GC- or LC-MS
Medchemexpress LLC MRL-494 hydrochloride | 2699937-04-5 | 98.6% | 100 MG
MRL-494 hydrochloride is an antibacterial agent that acts as an inhibitor of β-barrel assembly machine A (BamA). It is impervious to efflux and the outer membrane permeability barrier, and lethally disrupts the cytoplasmic membrane. It inhibits outer membrane proteins (OMPs) biogenesis by targeting BamA, demonstrating strong anti-microbial properties against various bacteria.
- Acts as an inhibitor of β-barrel assembly machine A (BamA)
- Impervious to efflux and outer membrane permeability barrier
- Lethally disrupts the cytoplasmic membrane
- Inhibits outer membrane proteins (OMPs) biogenesis
- Strong anti-microbial properties against Gram-positive bacteria (e.g., *Staphylococcus aureus* with MIC of 12.5 μM)
- Strong anti-microbial properties against Gram-negative bacteria (e.g., *E. coli* with MIC of 25 μM)
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 25mg
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
Sigma Aldrich Fine Chemicals Biosciences Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | MFCD00008365 | 5G
Curcumin from Curcuma longa (Turmeric), powder | Purity: >=65% (HPLC) | Mol Wt: 368.38 | 458-37-7 | MFCD00008365 | 5G
Medchemexpress LLC 1,6-heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)- | 458-37-7 | MFCD00008365 | 97.3% | 368.38 g·mol^-1 | C21H20O6 | 10 MG
Curcumin (diferuloylmethane) is a natural phenolic research reagent that functions as a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase. It modulates NF-κB and MAPK pathways, stabilizes Nrf2 through Keap1 cysteine modification, and exhibits anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic activities. Supplied as a characterized powder with recommended storage conditions and a COA.
Medchemexpress LLC Entacapone (Standard) | 130929-57-6 | 99.2% | C14H15N3O5 | 50 MG
Entacapone (Standard) is the analytical standard of Entacapone. It is a potent, reversible, peripherally acting, and orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits COMT from rat brain, erythrocytes, and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. It is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M), and PST-P (IC50s>50 μM).
- Used for research of Parkinson's disease
- Serves as an inhibitor of FTO demethylation with an IC50 of 3.5 μM, for research of metabolic disorders
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Intended for research and analytical applications
AdipoGen Curcumin
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.38. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4, tumorigenesis and development Shh, Gli, metabolism PPARgamma, Nrf2, epigenetics HDACs, HATs, DNA methyltransferase I and microRNAs and inflammation NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX.